HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butylamine → HCID 78323650, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 1325307-27-4 | HCID 53335886 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 78323650 | HCID 78323650 | 93.6% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(2-fluorophenyl)thiophene-2-carboxylate (100 mg, 0.40 mmol), triethyl orthoformate (1.0 ml), n-butylamine (0.076 ml, 0.76 mmol), and acetic acid (0.1 ml) were used to give 113.2 mg (0.37 mmol, 93.6% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-702c2e42f2794c759e96bb658ca1723b |
| Source note | uspto-grants-2016_02 |