HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → HCID 86729822, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Neopentylamine | HCID 79882 | — |
| Reactant | 1325307-27-4 | HCID 53335886 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 86729822 | HCID 86729822 | 76.3% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(2-fluorophenyl)thiophene-2-carboxylate (100 mg, 0.40 mmol), triethyl orthoformate (1 ml), neopentylamine (0.090 ml, 0.76 mmol), and acetic acid (0.1 ml) were used to give 96.5 mg (0.31 mmol, 76.3% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-bde3ab5d80044c4abf1d9770b316b29b |
| Source note | uspto-grants-2016_02 |