HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclooctylamine → HCID 86729823, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclooctylamine | HCID 2903 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Reactant | HCID 86729805 | HCID 86729805 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 86729823 | HCID 86729823 | 60.6% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(o -tolyl)thiophene-2-carboxylate (100 mg, 0.40 mmol), triethyl orthoformate (1 ml), cyclooctylamine (0.107 ml, 0.77 mmol), and acetic acid (0.1 ml) were used to give 85.4 mg (0.24 mmol, 60.6% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-cd60bff403814edfbdfc5367b9de1b90 |
| Source note | uspto-grants-2016_02 |