Chloroform → HCID 118194560, compound

Participants

Reaction Steps

To Compound 1 (130 mg, 0.235 mmol), water (10 mL), sodium hydrogen carbonate (200 mg, 2.33 mmol), chloroform (5 mL), tetrabutylammonium hydrogen sulfate (80 mg, 0.235 mmol), and bromomethyl acetate (0.120 mL, 1.22 mmol) were added, and the resulting mixture was vigorously stirred at room temperature for 3 hours. To the reaction mixture, a saturated aqueous ammonium chloride solution was added, and the resulting mixture was extracted with chloroform. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, and then, the solvent was evaporated under reduced, pressure. The resulting residue was purified by silica gel column chromatography (n-hexane/ethyl acetate), whereby Compound 27 (31.9 mg, 18%) and Compound 29 (23.9 mg, 19%) were obtained, respectively.

Provenance & Evidence