HCID 118415282, compound → HCID 118415264, compound

Participants

Reaction Steps

To above product (16) was added DEA (3 mL)/CH2Cl2 (3 mL). The reaction mixture was stirred at room temperature overnight. The reaction mixture was washed with water and dried over sodium sulphate. After concentrated in vacuo, the residue was purified by flash chromatography on silica-gel (MeOH/CH2Cl2, 1:10) to give the desired product 17 (121.0 mg, 58.4% for two steps). LC-MS: m/z 703.0[M+H]+; 1H NMR (400 MHz, DMSO) δ 8.41 (m, 2H), 7.30-7.11 (m, 5H), 4.80-4.10 (m, 4H), 4.00-3.50 (m, 3H), 3.35-2.65 (m, 14H), 2.44-1.90 (m, 4H), 1.89-1.60 (m, 5H), 1.60 (m, 20H), 1.15-0.70 (m, 6H).

Provenance & Evidence