(2-Bromoethyl)cyclohexane → HCID 117803011, compound

HRID 1775868Notes

Reaction equation

HRID 1775868 reaction equation
[C:1]([C:5]1[CH:46]=[CH:45][C:8]([C:9]([NH:11][C@@H:12]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]3[N:37]=[CH:36][C:35]([C:38]4[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][CH:39]=4)=[CH:34][N:33]=3)=[CH:28][CH:27]=2)[C:13]([NH:15][CH2:16][CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[O:14])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Br[CH2:48][CH2:49][CH:50]1[CH2:55][CH2:54][CH2:53][CH2:52][CH2:51]1>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([NH:11][C@@H:12]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]3[N:33]=[CH:34][C:35]([C:38]4[CH:43]=[CH:42][C:41]([O:44][CH2:48][CH2:49][CH:50]5[CH2:55][CH2:54][CH2:53][CH2:52][CH2:51]5)=[CH:40][CH:39]=4)=[CH:36][N:37]=3)=[CH:28][CH:27]=2)[C:13]([NH:15][CH2:16][CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[O:14])=[O:10])=[CH:45][CH:46]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 15440(2-Bromoethyl)cyclohexaneHCID 117748656HCID 117748656, compound

Product 1

HCID 117803011HCID 117803011, compound

Procedure

Prepared using General Procedure 12 from tert-butyl (S)-3-(2-(4-(tert-butyl)benzamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanamido)propanoate and (2-bromoethyl)cyclohexane. LCMS-ESI (m/z) calculated for C45H56N4O5: 732.9. found 733.5 [M+H]+, tR=5.59 min. (Method 16).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f8ad6b71019a46fcbdc7ef239b05d4fd
Source dataset
uspto-grants-2016_02
Patent number
US09260427B2

Reaction notes

Loading…