(4,4-Dimethoxybutyl)(methyl)amine → 2-(1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5-methyl-1H-indol-3-yl)-N-methylethanamine

HRID 1775896Notes

Reaction equation

HRID 1775896 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[N:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)N)=[CH:5][CH:4]=1.CO[CH:24](OC)[CH2:25][CH2:26][CH2:27][NH:28][CH3:29]>>[F:1][C:2]([F:21])([F:20])[C:3]1[N:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[C:13]3[C:18](=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=3)[C:25]([CH2:26][CH2:27][NH:28][CH3:29])=[CH:24]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 22563572(4,4-Dimethoxybutyl)(methyl)amineHCID 666017985-(2-(1-p-Tolylhydrazinyl)ethyl)-2-(trifluoromethyl)pyridine

Product 1

HCID 669117432-(1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5-methyl-1H-indol-3-yl)-N-methylethanamine

Procedure

The title compound is prepared by General Method 10 using 1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-1-p-tolylhydrazine (Example 2) and 4,4-dimethoxy-N-methylbutan-1-amine.

Sources & evidence

ORD record
ord-22bf5481b91242af9ce8e19c09ea16c0
Source dataset
uspto-grants-2016_02
Patent number
US09260429B2

Reaction notes

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