(4,4-Dimethoxybutyl)(methyl)amine → 2-(5-chloro-3-(2-(methylamino)ethyl)-1H-indol-1-yl)-1-(4-methylpiperidin-1-yl)ethanone

HRID 1775900Notes

Reaction equation

HRID 1775900 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH2:10][C:11]([N:13]2[CH2:18][CH2:17][CH:16]([CH3:19])[CH2:15][CH2:14]2)=[O:12])N)=[CH:4][CH:3]=1.CO[CH:22](OC)[CH2:23][CH2:24][CH2:25][NH:26][CH3:27]>>[Cl:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:8]([CH2:10][C:11]([N:13]1[CH2:18][CH2:17][CH:16]([CH3:19])[CH2:15][CH2:14]1)=[O:12])[CH:22]=[C:23]2[CH2:24][CH2:25][NH:26][CH3:27]

Participants

3

Reactant 2

HCID 22563572(4,4-Dimethoxybutyl)(methyl)amineHCID 669116852-(1-(4-Chlorophenyl)hydrazinyl)-1-(4-methylpiperidin-1-yl)ethanone

Product 1

HCID 669116502-(5-chloro-3-(2-(methylamino)ethyl)-1H-indol-1-yl)-1-(4-methylpiperidin-1-yl)ethanone

Procedure

The title compound is prepared by General Method 10 using 2-(1-(4-chlorophenyl)hydrazinyl)-1-(4-methylpiperidin-1-yl)ethanone (Example 6) and 4,4-dimethoxy-N-methylbutan-1-amine.

Sources & evidence

ORD record
ord-0d275b09ebd9411ebc3f39acf5b9e52c
Source dataset
uspto-grants-2016_02
Patent number
US09260429B2

Reaction notes

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