Formaldehyde → 9-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-2,3,4,9-tetrahydro-2,6-dimethyl-1H-pyrido[3,4-b]indole
Reaktionsgleichung
Cl.[C:2]1(C)C=CC(NN)=CC=1.BrCCC1C=CC(C(F)(F)F)=NC=1.FC(F)(F)C1N=CC(CCN(C2C=CC(C)=CC=2)N)=CC=1.C(OC(OCC)CCCNC)C.[F:57][C:58]([F:82])([F:81])[C:59]1[N:64]=[CH:63][C:62]([CH2:65][CH2:66][N:67]2[C:75]3[C:70](=[CH:71][C:72]([CH3:76])=[CH:73][CH:74]=3)[C:69]([CH2:77][CH2:78][NH:79][CH3:80])=[CH:68]2)=[CH:61][CH:60]=1.C=O.C(O)(C(F)(F)F)=O>C(#N)C.C(N(CC)CC)C>[F:82][C:58]([F:57])([F:81])[C:59]1[N:64]=[CH:63][C:62]([CH2:65][CH2:66][N:67]2[C:75]3[C:70](=[CH:71][C:72]([CH3:76])=[CH:73][CH:74]=3)[C:69]3[CH2:77][CH2:78][N:79]([CH3:2])[CH2:80][C:68]2=3)=[CH:61][CH:60]=1Komponenten
10
Edukt 7
HCID 712Formaldehyde
HCID 6422Trifluoroacetic acid
HCID 125044-Methylphenylhydrazine monohydrochloride
HCID 139945474,4-Diethoxy-N-methylbutan-1-amine
HCID 666017985-(2-(1-p-Tolylhydrazinyl)ethyl)-2-(trifluoromethyl)pyridine
HCID 668695375-(2-Bromoethyl)-2-(trifluoromethyl)pyridine
HCID 669117432-(1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5-methyl-1H-indol-3-yl)-N-methylethanamineProdukt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
The title compound is prepared by following General Methods 1, 3 and 4 using p-tolylhydrazine hydrochloride, 5-(2-bromoethyl)-2-(trifluoromethyl)pyridine, and triethylamine (General Method 1), 1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-1-p-tolylhydrazine (Example 2) and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3) and 2-(1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5-methyl-1H-indol-3-yl)-N-methylethanamine (Example 11), formaldehyde and TFA in acetonitrile (General Method 4).
Quellen und Nachweise
- ORD-Eintrag
- ord-37bf2433b8894cb29c2384aeb9217ec7
- Quelldatensatz
- uspto-grants-2016_02
- Patentnummer
- US09260429B2
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