HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-(7-chloro-2-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)-1-(6-methylpyridin-3-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | m-Chlorophenylhydrazine hydrochloride | HCID 75331 | — |
| Reactant | 4,4-Diethoxy-N-methylbutan-1-amine | HCID 13994547 | — |
| Reactant | [2-(6-Chloro-1h-indol-3-yl)ethyl](methyl)amine | HCID 21071655 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Sodium hydride | HCID 24758 | — |
| Solvent | 2-Methyl-5-(oxiran-2-yl)pyridine | HCID 15713588 | — |
| Solvent | 7-chloro-2-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole | HCID 57930478 | — |
| Product | 2-(7-chloro-2-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)-1-(6-methylpyridin-3-yl)ethanol | HCID 44242180 | — |
Reaction Steps
The title compound is prepared by following General Methods 3, 4 and 8 by using 3-chlorophenylhydrazine hydrochloride and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3), 2-(6-chloro-1H-indol-3-yl)-N-methylethanamine, formaldehyde and TFA in acetonitrile (General Method 4) and 7-chloro-2,3,4,9-tetrahydro-2-methyl-1H-pyrido[3,4-b]indole, 2-methyl-5-(oxiran-2-yl)pyridine and NaH (General Method 8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260429B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-fbb606610dc6429b864e1308942ab289 |
| Source note | uspto-grants-2016_02 |