HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 44242247, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) | HCID 71600 | — |
| Reactant | 4,4-Diethoxy-N-methylbutan-1-amine | HCID 13994547 | — |
| Reactant | HCID 44242581 | HCID 44242581 | — |
| Reactant | HCID 57930382 | HCID 57930382 | — |
| Reactant | HCID 57930384 | HCID 57930384 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Solvent | HCID 57930381 | HCID 57930381 | — |
| Product | HCID 44242247 | HCID 44242247 | — |
Reaction Steps
The title compound is prepared by following General Methods 1, 3, 4, 5 and 7 by using 4-chlorophenylhydrazine hydrochloride, ethyl bromoacetate, and triethylamine (General Method 1), ethyl 2-(1-(4-chlorophenyl)hydrazinyl)acetate and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3), ethyl 2-(5-chloro-3-(2-(methylamino)ethyl)-1H-indol-1-yl)acetate, formaldehyde and TFA in acetonitrile (General Method 4), ethyl 2-(6-chloro-1,2,3,4-tetrahydro-2-methylpyrido[3,4-b]indol-9-yl)acetate and NaOH (General Method 5), and 2-(6-chloro-1,2,3,4-tetrahydro-2-methylpyrido[3,4-b]indol-9-yl)acetic acid, N,N-dimethylamine and EDCI (General Method 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260429B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-aad9b8d909354103b4a301599d938362 |
| Source note | uspto-grants-2016_02 |