HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 68995990, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-Methylcyclohexylamine | HCID 7514 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 4,4-Diethoxy-N-methylbutan-1-amine | HCID 13994547 | — |
| Reactant | 3-Hydrazinylpyridine hydrochloride | HCID 23143454 | — |
| Reactant | HCID 66911711 | HCID 66911711 | — |
| Reactant | HCID 66911782 | HCID 66911782 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 68995990 | HCID 68995990 | — |
Reaction Steps
The title compound is prepared by following General Methods 1, 3, 4, 5 and 7 by using 1-(pyridin-3-yl)hydrazine hydrochloride and ethyl bromoacetate (General Method 1), ethyl 2-(1-(pyridin-3-yl)hydrazinyl)acetate and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3), ethyl 2-(3-(2-(methylamino)ethyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)acetate, formaldehyde and TFA in acetonitrile (General Method 4), ethyl 5-aza-2-(1,2,3,4-tetrahydro-2-methylpyrido[3,4-b]indol-9-yl)acetate and NaOH (General Method 5), and 5-aza-2-(1,2,3,4-tetrahydro-2-methylpyrido[3,4-b]indol-9-yl)acetic acid, N-methylcyclohexylamine and EDCI (General Method 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260429B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-7a3afc4cc4e44e738502ab6701aed093 |
| Source note | uspto-grants-2016_02 |