Formaldehyde → 6-chloro-2,3,4,9-tetrahydro-2-methyl-9-(2-(piperidin-1-yl)ethyl)-1H-pyrido[3,4-b]indole

HRID 1775943노트

반응식

HRID 1775943 반응식
Cl.ClC1C=CC(NN)=CC=1.Cl.Cl[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]([CH2:30][CH2:31][N:32]2[CH2:37][CH2:36][CH2:35]C[CH2:33]2)N)=[CH:24][CH:23]=1.C(OC(OCC)CCCNC)C.ClC1C=C2C(=CC=1)N(CCN1CCCCC1)C=C2CCNC.C=O.C(O)(C(F)(F)F)=O>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.C(#N)C>[Cl:21][C:22]1[CH:23]=[C:24]2[C:25](=[CH:26][CH:27]=1)[N:28]([CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:30]1[CH2:31][N:32]([CH3:33])[CH2:37][CH2:36][C:35]2=1

참가 물질

10

반응물 7

HCID 712FormaldehydeHCID 6422Trifluoroacetic acidHCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 139945474,4-Diethoxy-N-methylbutan-1-amineHCID 669116281-(4-Chlorophenyl)-1-(2-(piperidin-1-yl)ethyl)hydrazineHCID 669117682-(5-chloro-1-(2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)-N-methylethanamine

생성물 1

HCID 442424396-chloro-2,3,4,9-tetrahydro-2-methyl-9-(2-(piperidin-1-yl)ethyl)-1H-pyrido[3,4-b]indole

시약·촉매·용매 2

HCID 70681Tetrabutylammonium Chloride촉매HCID 6342Acetonitrile용매

실험 절차

The title compound was prepared by following General Methods 2, 3 and 4 using 4-chlorophenylhydrazine hydrochloride, 1-(2-chloroethyl)piperidine hydrochloride, and tetra-n-butylammonium chloride (General Method 2), 1-(4-chlorophenyl)-1-(2-(piperidin-1-yl)ethyl)hydrazine (Example 3) and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3) and 2-(5-chloro-1-(2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)-N-methylethanamine (Example 12), formaldehyde and TFA in acetonitrile (General Method 4).

출처 및 근거

ORD 기록
ord-cb7eaa3f6d224eaa804605f35d191e6b
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260429B2

반응 노트

불러오는 중…