HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 44242507, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | m-Tolylhydrazinium(1+) chloride | HCID 71562 | — |
| Reactant | 4,4-Diethoxy-N-methylbutan-1-amine | HCID 13994547 | — |
| Reactant | HCID 66911636 | HCID 66911636 | — |
| Reactant | HCID 66911675 | HCID 66911675 | — |
| Reactant | HCID 66911761 | HCID 66911761 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Solvent | HCID 66911710 | HCID 66911710 | — |
| Product | HCID 44242507 | HCID 44242507 | — |
Reaction Steps
The title compound is prepared by following General Methods 1, 3, 4, 5 and 7 by using m-tolylhydrazine hydrochloride, ethyl bromoacetate, and triethylamine (General Method 1), ethyl 2-(1-m-tolylhydrazinyl)acetate and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3), ethyl 2-(4-methyl-3-(2-(methylamino)ethyl)-1H-indol-1-yl)acetate, formaldehyde and TFA in acetonitrile (General Method 4), ethyl 2-(1,2,3,4-tetrahydro-2,5-dimethylpyrido[3,4-b]indol-9-yl)acetate and NaOH (General Method 5), and 2-(1,2,3,4-tetrahydro-2,5-dimethylpyrido[3,4-b]indol-9-yl)acetic acid, piperidine and EDCI (General Method 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260429B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-2451bb1cd9c442c6a8c116aae0945079 |
| Source note | uspto-grants-2016_02 |