HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 44242509, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Methylphenylhydrazine monohydrochloride | HCID 12504 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Ethyl 3-bromopropionate | HCID 68320 | — |
| Reactant | 4,4-Diethoxy-N-methylbutan-1-amine | HCID 13994547 | — |
| Reactant | HCID 66911689 | HCID 66911689 | — |
| Reactant | HCID 66911780 | HCID 66911780 | — |
| Reactant | HCID 66911788 | HCID 66911788 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Solvent | HCID 66911763 | HCID 66911763 | — |
| Product | HCID 44242509 | HCID 44242509 | — |
Reaction Steps
The title compound is prepared by following General Methods 1, 3, 4, 5 and 7 by using p-tolylhydrazine hydrochloride, ethyl 3-bromopropionate, and triethylamine (General Method 1), ethyl 3-(1-p-tolylhydrazinyl)propanoate and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3), ethyl 3-(5-methyl-3-(2-(methylamino)ethyl)-1H-indol-1-yl)propanoate, formaldehyde and TFA in acetonitrile (General Method 4), ethyl 3-(1,2,3,4-tetrahydro-2,6-dimethylpyrido[3,4-b]indol-9-yl)propanoate and NaOH (General Method 5), and 3-(1,2,3,4-tetrahydro-2,6-dimethylpyrido[3,4-b]indol-9-yl)propanoic acid, piperidine and EDCI (General Method 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260429B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-a2e84cf252dc4bc3835776c0c8f5f1cf |
| Source note | uspto-grants-2016_02 |