6-Aminohexanoic Acid → 6-(((Phenylmethoxy)carbonyl)amino)hexanoic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-Amino hexanoic acid (50 grams, 379.65 mmol) in 1N Sodium hydroxide (95.3 ml) is cooled to 5 to 10° C. and simultaneously added from two separating funnels 4N Sodium hydroxide (190.6 ml) and Benzyl chloroformate (50% in Toluene, 196 grams) keeping the temperature at 5 to 10° C., later stirred at the same temperature for 2 hours and allowed to room temperature and stirred overnight. The reaction mixture is washed with Diisopropyl ether (3×200 ml), cooled to 10° C.; pH adjusted to 2 with dilute HCl, residue precipitated is filtered, dried and slurried in Diisopropyl ether to give pure 6-Benzyloxycarbonylamino hexanoic acid (38 grams) as white powder.

Provenance & Evidence