HCID 86663808, compound → HCID 86710489, compound

HRID 1775995Notes

Reaction equation

HRID 1775995 reaction equation
[F:1][C:2]([F:22])([CH:7]([O:11][C:12](=[O:21])[C:13]([F:20])([F:19])[CH:14]([OH:18])[CH:15]([CH3:17])[CH3:16])[CH:8]([CH3:10])[CH3:9])[C:3]([O:5][CH3:6])=[O:4].FC(F)([CH:41]([OH:45])[CH:42]([CH3:44])[CH3:43])C(OCC(F)(F)C(F)(F)C(F)(F)C(F)F)=O>>[F:1][C:2]([F:22])([CH:7]([O:11][C:12](=[O:21])[C:13]([F:19])([F:20])[CH:14]([O:18][C:41](=[O:45])[C:42]([CH3:44])=[CH2:43])[CH:15]([CH3:16])[CH3:17])[CH:8]([CH3:10])[CH3:9])[C:3]([O:5][CH3:6])=[O:4]

Participants

3

Reactant 2

HCID 86663808HCID 86663808, compoundHCID 86710490HCID 86710490, compound

Product 1

HCID 86710489HCID 86710489, compoundYield 49%

Procedure

Reaction was conducted by the same procedure as Example 11 aside from using methyl 2,2-difluoro-3-(2,2-difluoro-3-hydroxy-4-methylpentanoyloxy)-4-methylpentanoate in Example 11-1 instead of 2,2,3,3,4,4,5,5-octafluoropentyl 2,2-difluoro-3-hydroxy-4-methylpentanoate in Example 11-3. Subsequent purification was conducted by silica gel column chromatography instead of vacuum distillation. The target compound, methyl 2,2-difluoro-3-(2,2-difluoro-3-methacryloyloxy-4-methylpentanoyloxy)-4-methylpentanoate was obtained in a yield of 49%.

Workup

  1. customReaction
  2. customSubsequent purification
  3. distillationwas conducted by silica gel column chromatography instead of vacuum distillation

Sources & evidence

ORD record
ord-8f02e568744a48b6ba50f48b8d45e9cd
Source dataset
uspto-grants-2016_02
Patent number
US09261783B2

Reaction notes

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