HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid → 4-(piperazin-1-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid | HCID 2795508 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(piperazin-1-yl)benzoic acid | HCID 1180477 | 90.6% |
Reaction Steps
A mixture of 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzoic acid (28 g, 91 mmol) in hydrochloric acid in methanol (300 mL) was stirred at room temperature for 4 h. The resulting precipitate was collected by filtration and concentrated to dryness to provide the title compound (17 g, 61% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260414B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-30e565770c7d4f62af718843aee8de94 |
| Source note | uspto-grants-2016_02 |