HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Bromo-3-fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Bromo-3-fluorobenzoic acid | HCID 2773341 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-3-fluorobenzoyl chloride | HCID 22626891 | — |
Reaction Steps
Oxalyl dichloride (6.1 g, 48 mmol) was added to a solution of 4-bromo-3-fluoro-benzoic acid (7 g, 32 mmol) in DCM (80 mL) at 0° C. followed by DMF (0.2 mL) and the reaction mixture was stirred at RT for 2 h and then concentrated under vacuum to provide crude 4-bromo-3-fluoro-benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260414B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5f7de4bbd78640dea8b25d5a6b8ee396 |
| Source note | uspto-grants-2016_02 |