HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 14129197, compound → HCID 86664803, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 14129197 | HCID 14129197 | — |
| Reactant | 2-Fluoropyridine-5-carbonyl chloride | HCID 14623602 | — |
| Catalyst | Dimethylacetamide | HCID 31374 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86664803 | HCID 86664803 | — |
Reaction Steps
To a solution of 4-bromo-2-fluoro-5-trifluoromethoxy-phenylamine (500 mg, 2 mmol) dissolved in DCM (1 mL) was slowly added a solution of 2-fluoropyridine-5-carbonyl chloride (290 mg, 1.8 mmol) in DCM (1 mL). A few drops of DMA were added and the reaction mixture was concentrated to form N-(4-bromo-2-fluoro-5-trifluoromethoxy-phenyl)-6-fluoro-nicotinamide as a purple solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260414B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-bdb4891b15a741ad923b21abed78cc47 |
| Source note | uspto-grants-2016_02 |