Dimethylacetamide → HCID 178502391, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-[(R)-4-((S)-2,2-dimethyl-cyclopropanecarbonyl)-2-methyl-piperazin-1-yl]-nicotinic acid (4.54 mg, 0.014 mmol; Preparation 36), HCTU (8.0 mg, 0.019 mmol), N,N-diisopropylethylamine (0.013 mL, 0.072 mmol), and DMA (0.2 mL, 2 mmol) was stirred for 30 min at 50° C. and then ((S)-1-{(S)-2-[4-(4′-amino-2′-chloro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (7.1 mg, 0.014 mmol; Preparation 37) was added. The reaction mixture was stirred overnight and then HCTU (8 mg) was added and the reaction mixture was heated to 55° C. After 5 h, the reaction mixture was cooled to RT, ethyl acetate and water were added. The organic layer was concentrated under vacuum and purified by preparative HPLC to provide the di-TFA salt of the title compound (1.3 mg). (m/z): [M+H]+ calcd for C43H51ClN8O5 795.37 found 795.4.

Provenance & Evidence