HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-(Quinolin-2-ylmethoxy)phenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 2-(4-(quinolin-2-ylmethoxy)phenyl)acetate | HCID 58368005 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-(Quinolin-2-ylmethoxy)phenyl)acetic acid | HCID 14500235 | 119.3% |
Reaction Steps
To a solution of ethyl 2-(4-(quinolin-2-ylmethoxy)phenyl)acetate (8 g, 0.02 mol) in MeOH: THF (300 mL; 1:1) was added LiOH.H2O (5.21 g, 0.124 mol) and the mixture was stirred at RT for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude compound. The crude material was acidified with HCl (1N), filtered and dried in vacuo to afford 2-(4-(quinolin-2-ylmethoxy)phenyl)acetic acid (7.0 g, 95%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09265767B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-51e579a32de54fc89258e2079fbf7cb4 |
| Source note | uspto-grants-2016_02 |