4-Acetylpyridine → 4-(Bromoacetyl)pyridine hydrobromide

Participants

Reaction Steps

To a stirred solution of 1-(pyridin-4-yl)-ethanone (10 g, 0.08 mol) in CCl4 (150 mL) was added Br2 (3.99 mL, 0.02 mol) dropwise at 0° C. and the mixture was then refluxed for 1 h. The reaction mixture was filtered and dried in vacuo to afford 2-bromo-1-(pridin-4-yl)-ethanone hydrobromide (22 g, 94%) as a solid.

Provenance & Evidence