(Pyridin-4-yl)boronic acid → HCID 44539913, compound

HRID 1776262Notes

Reaction equation

HRID 1776262 reaction equation
COC1C=CC([C:9]2[C:13]([CH3:15])([CH3:14])[O:12][C:11](=[O:16])[C:10]=2[C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24]C3C=CC4C(=CC=CC=4)N=3)=[CH:19][CH:18]=2)=CC=1.[N:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1>>[CH3:14][C:13]1([CH3:15])[O:12][C:11](=[O:16])[C:10]([C:17]2[CH:18]=[CH:19][C:20]([O:23][CH2:24][C:36]3[CH:37]=[CH:38][C:39]4[C:40](=[CH:13][CH:9]=[CH:10][CH:11]=4)[N:35]=3)=[CH:21][CH:22]=2)=[C:9]1[C:38]1[CH:39]=[CH:40][N:35]=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 44594753HCID 44594753, compound

Product 1

HCID 44539913HCID 44539913, compoundYield 76%

Procedure

Following the procedure for the preparation of 4-(4-methoxyphenyl)-5,5-dimethyl-3-(4-(quinolin-2-ylmethoxy)phenyl)furan-2(5H)-one (Example 33) using pyridine-4-yl boronic acid provided the title compound.

Sources & evidence

ORD record
ord-057acffdf1bc4645b924d1eca47d3d91
Source dataset
uspto-grants-2016_02
Patent number
US09265767B2

Reaction notes

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