N,N-Diethylaniline → HCID 86732430, compound

Participants

Reaction Conditions

Reaction Steps

88 mg of sodium 5-carbamoyl-2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]pyrimidin-4-olate (1-13-1, 0.228 mmol, 1 eq.) were suspended in 0.915 ml of phosphoric trichloride (9.82 mmol, 43 eq.) and 69 μl of N,N-diethylaniline (0.457 mmol, 2 eq.). The suspension was stirred at 90° C. bath temperature for 24 hours and then dropped to an ice cooled saturated aqueous sodium hydrogen carbonate solution. The resulting suspension was filtered off and dried in vacuo to yield 82 mg (0.21 mmol, 93.77%) of the analytically pure target compound.

Provenance & Evidence