HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1776459Generated: October 30, 2026
HCID 89455778, compound → (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)-benzamido)acetoxy)ethyl)pyridine 1-oxide
https://huagongshe.com/reaction/1776459
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 89455778 | HCID 89455778 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)-benzamido)acetoxy)ethyl)pyridine 1-oxide | HCID 71508338 | 8.1% |
Reaction Steps
(S)-4-(2-(2-(4-(N-(tert-butoxycarbonyl)methylsulfonamido)-3-(cyclopropylmethoxy)benzamido)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide (180 mg, 0.2 mmol) was dissolved in HCl 4M in EtOAc and stirred overnight at 0° C. The solvent was evaporated under vacuum, and the crude product was purified by Preparative reverse-phase HPLC to give 12 mg of the final product (Yield: 8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09265768B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-1e517763340a42cd88a7dceed2c9e99b |
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| Source note | uspto-grants-2016_02 |
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