HCID 86679424, compound → HCID 86679425, compound

Participants

Reaction Steps

Tert-Butyl 4-methoxy-3-nitrobenzyl(methyl)carbamate (333 mg, 1.124 mmol) was dissolved in EtOAc (20 ml), Pt2O (33 mg, 0.145 mmol) was added, and the mixture was hydrogenated in a Parr apparatus at 20 psi for 3 hours. The solution was filtered and evaporated to dryness to give tert-butyl 3-amino-4-methoxybenzyl(methyl)carbamate (265.3 mg, 0.996 mmol, 89% yield, MS/ESI+ 289.2 [MNa]+) that was used in the next step without further purification.

Provenance & Evidence