Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

tert-Butyl 4-methoxy-3-(methylsulfonamido)benzyl(methyl)carbamate (60.4 mg, 0.175 mmol) was dissolved in DCM (5 ml), HCl 4M in dioxane (250 μl, 1.000 mmol) was added, and the reaction was stirred at RT overnight. Additional HCl 4M in dioxane (500 μl, 2.00 mmol) was added over 30 hours with stirring at the same temperature. The solvent was evaporated under vacuum, and the solid so obtained was triturated in DCM and filtered to give N-(2-methoxy-5-((methylamino)methyl)-phenyl)methanesulfonamide as hydrochloride (42.8 mg, 0.175 mmol, 100% yield, MS/ESI+ 245.3 [MH]+) that was used in the next step without further purification.

Provenance & Evidence