Dichloromethane → HCID 86719335, compound

Participants

Reaction Steps

To a solution of 4-((S)-2-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-(trityloxy)butanoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)ethyl)-3,5-dichloropyridine 1-oxide (354 mg, 0.354 mmol) in DCM (5 mL), 4-methylbenzenesulfonic acid hydrate (14 mg, 0.071 mmol) was added. The mixture was stirred at room RT overnight. The mixture was then diluted with DCM and washed with NaHCO3 sat. sol. The organic phase was dried over Na2SO4, and the solvent was evaporated, to yield 268 mg of the title compound.

Provenance & Evidence