Acetyl chloride → HCID 86679435, compound

Participants

Reaction Steps

To a solution of 4-((S)-2-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-hydroxypentanoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-ethyl)-3,5-dichloropyridine 1-oxide (268 mg, 0.354 mmol) in DCM (5 mL), acetyl chloride (54 μl, 0.757 mmol) and TEA (108 μl, 0.775 mmol) were added. The mixture was stirred at RT for 3 hours. The mixture was then diluted with DCM and washed with NaHCO3 sat. sol., HCl 0.1 M and brine. The organic phase was dried over Na2SO4 and the solvent was evaporated, to yield 284 mg of the title compound.

Provenance & Evidence