Hydrochloric Acid → HCID 86679446, compound

Participants

Reaction Steps

To a solution of ethyl 2-(tert-butoxycarbonyl(3,4-dimethoxybenzyl)amino)-acetate (0.260 g, 0.736 mmol) in THF (1.5 ml), lithium hydroxide 1N (0.883 ml, 0.883 mmol) was added, and the reaction was stirred at RT for 4 hours. The mixture was diluted with EtOAc (15 ml) and acidified with HCl 1M. The organic phase was washed with brine and dried over Na2SO4; the solvent was evaporated to dryness affording 2-(tert-butoxycarbonyl(3,4-dimethoxybenzyl)amino)acetic acid as a yellow oil (0.233 g, 0.716 mmol, 97% yield, MS/ESI+ 348.1 [MNa]+). This product was used without any further purification.

Provenance & Evidence