1,4-Dioxane → HCID 86679448, compound

Participants

Reaction Steps

To a solution of (S)-4-(2-(2-(tert-butoxycarbonyl(3,4-dimethoxybenzyl)-amino)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide (258 mg, 0.355 mmol) in DCM (24 ml), HCl 4M in dioxane (1.2 ml, 4.80 mmol) was added drop wise, and the reaction was stirred at RT overnight. The volatiles were evaporated under vacuum and the residue was purified by trituration with diethylether affording (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino) acetoxy)ethyl)pyridine 1-oxide hydrochloride as a beige solid (0.187 g, 0.282 mmol, 79% yield, MS/ESI+ 626.82 [MH]+, [αD]=−15.57, c=0.56, MeOH).

Provenance & Evidence