Lithium Hydroxide → HCID 89459914, compound

Participants

Reaction Steps

To a solution of allyl 2-((4-(N-(tert-butoxycarbonyl)methylsulfonamido)-benzyl)(methyl)amino)acetate (0.390 g, 0.945 mmol) in THF (22 ml), LiOH 1N (0.945 ml, 0.945 mmol) was added, and the mixture was stirred at RT for 3 days. The mixture was diluted with water and washed twice with EtOAc. The aqueous phase was acidified with 0.189 ml of HCl 1N and frozen dry. The residue was dissolved in DCM/MeOH and transferred in a small container. 2-((4-(N-(tert-butoxycarbonyl)methylsulfonamido)-benzyl)(methyl)amino)acetic acid was obtained (0.313 g, 0.840 mmol, 89% yield, MS/ESI+ 373.2 [MH]+) and used without any further purification.

Provenance & Evidence