反应详情

A solution of tert-butyl 3-(trityloxy)propanoate (3.5 g, 9.01 mmol) and 6M NaOH (3.00 ml, 18.02 mmol) in ethanol was heated to reflux for 3 hours. After cooling the solvent was removed under vacuum and the residue was partitioned between DCM and aqueous 3% citric acid. The organic layer was washed with brine dried over Na2SO4. The solvent was evaporated and the crude was triturated with iPr2O and filtered affording 3-(trityloxy)propanoic acid (2.3 g, 6.92 mmol, 77% yield).

1. temperatureto reflux for 3 hours
2. temperatureAfter cooling the solvent
3. customwas removed under vacuum
4. customthe residue was partitioned between DCM and aqueous 3% citric acid
5. washThe organic layer was washed with brine
6. dry with materialdried over Na2SO4
7. customThe solvent was evaporated
8. customthe crude was triturated with iPr2O
9. filtrationfiltered