Carbon tetrabromide → HCID 86679484, compound

Participants

Reaction Steps

To a solution of methyl 3-(cyclopropylmethoxy)-4-(N-(2-hydroxyethyl)-methylsulfonamido)benzoate (0.690 g, 2.009 mmol) in dry DCM (15 ml), CBr4 (0.866 g, 2.61 mmol) was added, followed by triphenylphosphine (0.685 g, 2.61 mmol), and stirring was continued for 2 hours at RT. The solvent was evaporated, and the residue was purified by flash chromatography on silica gel (eluent: EtOAc/petroleum ether 2/8) to give methyl 4-(N-(2-bromoethyl)methylsulfonamido)-3-(cyclopropylmethoxy)benzoate as a colorless oil (0.630 g, 1.551 mmol, 77% yield, MS/ESI+ 405.8, [MH]+).

Provenance & Evidence