Potassium Carbonate → HCID 86679485, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of methyl 4-(N-(2-bromoethyl)methylsulfonamido)-3-(cyclopropylmethoxy)benzoate (630 mg, 1.551 mmol), 1-methylpiperazine (155 mg, 1.551 mmol) and K2CO3 (321 mg, 2.326 mmol) in dry CH3CN (14 ml) was heated at 130° C. under microwave irradiation for 3 hours. After cooling the inorganic salts were filtered, the solvent was evaporated and the residue was purified by flash chromatography on silica gel (eluent: DCM/MeOH/32% NH4OH 95/5/0.5) to give methyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)-methylsulfonamido)benzoate as a light brown oil (520 mg, 1.222 mmol, 79% yield, MS/ESI+ 426.0 [MH]+).

Provenance & Evidence