Lithium Hydroxide → HCID 86679486, compound

Participants

Reaction Steps

To a solution of methyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate (370 mg, 0.869 mmol) in THF (3 ml), a solution of LiOH 1M (43.8 mg, 1.043 mmol) was added. The final solution was stirred at RT for 6 hours, then the solvent was evaporated and the residue was dried under vacuum to give lithium 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methyl-sulfonamido)benzoate as a pale yellow solid (380 mg, yield considered to be quantitative, MS/ESI+ 412.0 [MH]+) that was used in the following step without further purification.

Provenance & Evidence