HCID 86679488, compound → HCID 86679489, compound

Participants

Reaction Steps

The mixture of 2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate (370 mg, 0.661 mmol) and a catalytic amount of 10% Pd/C in MeOH (20 ml) was hydrogenated at 20 psi for 2 hours. The catalyst was filtered off and the solvent was evaporated to give 2-(3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)-benzoyloxy)acetic acid (270 mg, 0.575 mmol, 87% yield, MS/ESI+ 470.0 [MH]+) that was used in the following step without further purification.

Provenance & Evidence