Hydrochloric Acid → HCID 89455725, compound

Participants

Reaction Steps

To a solution of methyl 3-(N-(tert-butoxycarbonyl)methylsulfonamido)-4-methoxybenzoate (0.882 g, 2.454 mmol) in THF (15 ml), LiOH 1N (2.94 ml, 2.94 mmol) was added and the mixture was stirred at RT for 24 hours. The mixture was acidified with HCl 1N and extracted with EtOAc; the organic phase was washed with brine ad dried over Na2SO4. The solvent was removed and the residue was triturated with Et2O to afford after filtration 3-(N-(tert-butoxycarbonyl)-methylsulfonamido)-4-methoxybenzoic acid (0.487 g, 1.410 mmol, 57.5% yield, MS/ESI+ 367.9 [MNa]+).

Provenance & Evidence