Methanesulfonyl chloride → HCID 86679496, compound

Participants

Reaction Steps

Benzyl 3-amino-4-methoxybenzoate (300 mg, 1.17 mmol) was dissolved in Py (5 ml). Methanesulfonyl chloride (140 mg, 1.22 mmol) was added at 0° C. and under Argon atmosphere. The mixture was stirred at RT for 1 hour, then it was diluted with HCl 1N and extracted with EtOAc. The organic phase was washed with HCl 1M, dried over Na2SO4 and concentrated under vacuum to give benzyl 4-methoxy-3-(methylsulfonamido)benzoate (247 mg, 63.2% yield).

Provenance & Evidence