Potassium Carbonate → HCID 86679502, compound

Participants

Reaction Conditions

Reaction Steps

Benzyl 4-methoxy-3-(methylsulfonamido)benzoate (1.5 g, 4.47 mmol, Compound 144 may be prepared in analogous manner as described in Scheme 19, Step 1 and 2) was dissolved in DMF (10 ml), then 4-(2-chloroethyl)morpholine (6.69 g, 44.7 mmol) and K2CO3 (1.23 g, 8.94 mmol) were added, and the mixture was stirred at 80° C. for 3 hours. The reaction was quenched with water, and the product was extracted with EtOAc. The organic phase was washed with water (3×), then dried over Na2SO4 and evaporated under vacuum to yield 1.5 g of crude.

Provenance & Evidence