反应详情

To a suspension of ethyl 2-(trityloxy)acetate (8.2 g, 23.67 mmol) in EtOH (350 ml), NaOH 6M (7.89 ml, 47.3 mmol) was added at RT. The suspension slowly turned into a solution. After 1 hour, EtOH was removed under vacuum and the remaining crude was partitioned between HCl 2N and DCM. The organic phase was separated, dried over Na2SO4 and evaporated under vacuum. 2-(Trityloxy)acetic acid was obtained (7.42 g, 23.31 mmol, 98% yield) and used as such in the following reaction without further purification.

1. additionwas added at RT
2. customEtOH was removed under vacuum
3. customthe remaining crude was partitioned between HCl 2N and DCM
4. customThe organic phase was separated
5. dry with materialdried over Na2SO4
6. customevaporated under vacuum