HCID 86679535, compound → HCID 86679536, compound

Participants

Reaction Steps

A mixture of 2-(benzyloxy)-2-oxoethyl 2-(tert-butoxycarbonyloxy)-5-(N-(cyclopropylmethyl)methylsulfonamido)benzoate (0.288 g, 0.540 mmol) and 10% w/w Pd/C (0.030 g, 0.028 mmol) in MeOH (20 ml) and EtOAc (5 ml) was hydrogenated at 20 psi for 3 hours. The catalyst was filtered off and the solvent was removed affording 2-(2-(tert-butoxycarbonyloxy)-5-(N-(cyclopropylmethyl)-methylsulfonamido)benzoyloxy)-acetic acid (0.215 g, 0.485 mmol, 90% yield). This product was used without purification.

Provenance & Evidence