Methanesulfonyl chloride → HCID 46181731, compound

Participants

Reaction Steps

(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoate (500 mg, 1.7 mmol) was dissolved in DCM (10 ml), and TEA (343 mg, 3.4 mmol) and methanesulfonyl chloride (290 mg, 2.6 mmol) were added. The mixture was stirred at RT for 2 hours, then was washed with HCl 1N (2×). The organic layer was dried over Na2SO4 and evaporated under vacuum to give 570 mg (90%) of the title compound which was employed in the next step without any further purification. MS/ESI+ 374.12 [MH]+.

Provenance & Evidence