Hydrochloric Acid → HCID 86679572, compound

Participants

Reaction Steps

(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(methylsulfonyloxy)phenyl)-propanoate (300 mg, 0.8 mmol) was dissolved in THF (5 ml), and LiOH 1M (2 ml) was added. The mixture was stirred at RT for 5 hours, then HCl 1M was added, and the product was extracted with EtOAc. The organic layer was dried over Na2SO4 and evaporated under vacuum to give 229 mg (80%) of the title compound which was employed in the next step without any further purification. MS/ESI+ 360.39 [MH]+.

Provenance & Evidence