Hydrochloric Acid → HCID 86719337, compound

Participants

Reaction Steps

4-((S)-2((S)-2-(tert-butoxycarbonylamino)-3-(4-(methylsulfonyloxy)-phenyl)propanoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-ethyl)-3,5-dichloropyridine 1-oxide (100 mg, 0.13 mmol) was dissolved in EtOAc (2 ml), and then HCl 7M in EtOAc (2 ml) was added. The mixture was stirred at RT for 3 hours, then was washed with WATER (2×). The crude was purified by preparative reverse-phase HPLC to give 69 mg (80%) of the title compound.

Provenance & Evidence