Sodium Hydroxide → HCID 24262708, compound

Participants

Reaction Steps

Benzyl 2-(3,4-dimethoxyphenylsulfonyloxy)acetate (400 mg, 1.092 mmol) was dissolved in MeOH (5 ml). NaOH 1M (2 ml) was added, and the reaction was stirred at RT for 6 hours to achieve completion. The reaction mixture was diluted with HCl 1N and extracted with EtOAc. The organic phase was washed with HCl 1N and brine, dried over Na2SO4 and concentrated under vacuum. The crude product was triturated in petroleum ether to give 2-(3,4-dimethoxyphenylsulfonyloxy)acetic acid (250 mg, 83% yield).

Provenance & Evidence