HCID 10104519, compound → Methyl 3-(4-aminophenyl)propanoate

HRID 1776627Notes

Reaction equation

HRID 1776627 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 10104519HCID 10104519, compound

Product 1

HCID 417374Methyl 3-(4-aminophenyl)propanoateYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Methyl 3-(4-nitrophenyl)propanoate (450 mg, 2.151 mmol) was dissolved in MeOH (10 ml) and then Pd/C 5% (458 mg, 0.215 mmol) was added. The solution was shaken under hydrogen atmosphere at 35 psi for 30 minutes on a Parr apparatus. The catalyst was filtered off and the solvent removed under vacuum to give methyl 3-(4-aminophenyl)propanoate (350 mg, 1.953 mmol, 91% yield).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-89661deeb7974b6b9ef8f93d5e4acc73
Source dataset
uspto-grants-2016_02
Patent number
US09265768B2

Reaction notes

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