1,2-Dichloroethane → HCID 89455515, compound

Participants

Reaction Steps

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide (30 mg, 0.07 mmol) and 3-(4-(N-(tert-butoxycarbonyl)methylsulfonamido)phenyl)propanoic acid (48 mg, 0.14 mmol) were dissolved in DMF (2 ml), and DMAP (17 mg, 0.14 mmol) and EDC (40 mg, 0.21 mmol) were added. The mixture was stirred at RT overnight, then was diluted with water. The precipitate was filtered, dissolved in EtOAc and washed with HCl 1N and NaHCO3 sat. sol. The organic phase was dried over Na2SO4 and evaporated under vacuum to give 40 mg of crude product, that was used for the next step without any further purification.

Provenance & Evidence