Hydrochloric Acid → HCID 71542077, compound

Participants

Reaction Steps

(S)-4-(2-(3-(4-(N-(tert-butoxycarbonyl)methylsulfonamido)-phenyl)propanoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-ethyl)-3,5-dichloropyridine 1-oxide (40 mg, 0.05 mmol) was dissolved in DCM (1.5 ml), then HCl 4M in Dioxane (1 ml, 4 mmol) was added, and the mixture was stirred at RT for 5 hours. The reaction was diluted with DCM and washed with water. The organic phase was dried over Na2SO4 and evaporated under vacuum. The crude product was purified by Preparative reverse-phase HPLC to yield 20 mg of final product (Yield: 62%).

Provenance & Evidence